We combine chemical biology, molecular genetic, and genome editing tools to understand how eukaryotic translation initiation regulates and molds the cellular proteome. As well, by integrating our approaches with powerful cancer models we seek to understand how translation can be targeted as a vulnerability in cancer progression and drug resistance.
Jerry Pelletier is a James McGill Professor in the Departments of Biochemistry and Oncology at McGill University and a member of The Rosalind and Morris Goodman Cancer Research Center. Dr. Pelletier is a biochemist and molecular biologist who received his Ph.D. from McGill University under Dr. Nahum Sonenberg in 1988. He trained as a post-doctoral fellow with Dr. David Housman at the MIT Center for Cancer Research from 1988-1991. He then joined McGill University in 1991 and was promoted to full professor in 2002. His interest is on diverse aspects of eukaryotic translation initiation - with a recent focus on applying chemical biology and genetic tools to better understand the molecular mechanisms that regulate ribosome recruitment to mRNAs.
Dr. Pelletier is a full member of the Department of Biochemistry, Department of Oncology and The Rosalind and Morris Goodman Cancer Research Center. As well, he is a member of the Centre de Recherche en Biologie Structurale, a center funded by the FRQ-S. https://www.crbsmcgill.ca